!Series_title "Lymphocyte gene expression data from moderate stage HD patients and controls" !Series_geo_accession "GSE8762" !Series_status "Public on Aug 15 2007" !Series_submission_date "Aug 13 2007" !Series_last_update_date "Dec 03 2007" !Series_pubmed_id "17724341" !Series_summary "Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a large battery of transcriptomic tests explored as state biomarker candidates. In an attempt to exploit the known neuroinflammatory and transcriptional perturbations of disease, we measured relevant mRNAs in peripheral blood cells. The performance of these potential markers was weak overall, with only one mRNA, immediate early response 3 (IER3), showing a modest but significant increase of 32% in HD samples compared to controls. No statistically significant differences were found for any other mRNAs tested, including a panel of 12 RNA biomarkers identified in a previous report [Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV et al. (2005) Proc Natl Acad Sci U S A 102: 11023-11028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies." !Series_overall_design "Lymphocyte samples from 12 moderate stage HD patients (8 female and 4 male) and 10 age-matched controls (5 female and 5 male)." !Series_type "RNA biomarker screen" !Series_contributor "Heike,,Runne" !Series_contributor "Alexandre,,Kuhn" !Series_contributor "Edward,J,Wild" !Series_contributor "Wirahpati,,Pratyaksha" !Series_contributor "Mark,,Kristiansen" !Series_contributor "Jeremy,D,Isaacs" !Series_contributor "Etienne,,Régulier" !Series_contributor "Mauro,,Delorenzi" !Series_contributor "Sarah,J,Tabrizi" !Series_contributor "Ruth,,Luthi-Carter" !Series_sample_id "GSM217766 GSM217767 GSM217768 GSM217769 GSM217770 GSM217771 GSM217772 GSM217773 GSM217774 GSM217775 GSM217776 GSM217777 GSM217778 GSM217779 GSM217780 GSM217781 GSM217782 GSM217783 GSM217784 GSM217785 GSM217786 GSM217787 " !Series_contact_name "Alexandre,,Kuhn" !Series_contact_email "alexandre.kuhn@epfl.ch" !Series_contact_laboratory "Laboratory of Functional Neurogenomics" !Series_contact_department "Life Sciences" !Series_contact_institute "EPFL" !Series_contact_address "Station 15" !Series_contact_city "Lausanne" !Series_contact_zip/postal_code "1015" !Series_contact_country "Switzerland" !Series_supplementary_file "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/series/GSE8762/GSE8762_RAW.tar" !Series_platform_id "GPL570" !Sample_title "lymphocytes_ctl_F_30y" "lymphocytes_ctl_F_39y" "lymphocytes_ctl_F_51y" "lymphocytes_ctl_F_60y" "lymphocytes_ctl_F_68y" "lymphocytes_ctl_M_38y" "lymphocytes_ctl_M_42y" "lymphocytes_ctl_M_46y" "lymphocytes_ctl_M_50y" "lymphocytes_ctl_M_60y" "lymphocytes_HD_F_36y" "lymphocytes_HD_F_41y" "lymphocytes_HD_F_43y_1" "lymphocytes_HD_F_43y_2" "lymphocytes_HD_F_44y" "lymphocytes_HD_F_50y" "lymphocytes_HD_F_56y" "lymphocytes_HD_F_61y" "lymphocytes_HD_M_51y" "lymphocytes_HD_M_55y" "lymphocytes_HD_M_59y" "lymphocytes_HD_M_62y" !Sample_geo_accession "GSM217766" "GSM217767" "GSM217768" "GSM217769" "GSM217770" "GSM217771" "GSM217772" "GSM217773" "GSM217774" "GSM217775" "GSM217776" "GSM217777" "GSM217778" "GSM217779" "GSM217780" "GSM217781" "GSM217782" "GSM217783" "GSM217784" "GSM217785" "GSM217786" "GSM217787" !Sample_status "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" "Public on Aug 15 2007" !Sample_submission_date "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" !Sample_last_update_date "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" "Aug 13 2007" !Sample_type "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" "RNA" !Sample_channel_count "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" !Sample_source_name_ch1 "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" "lymphocytes (blood)" !Sample_organism_ch1 "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" "Homo sapiens" !Sample_characteristics_ch1 "Sample Group: control; Gender: female; Age: 30; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: female; Age: 39; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: female; Age: 51; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: female; Age: 60; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: female; Age: 68; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: male; Age: 38; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: male; Age: 42; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: male; Age: 46; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: male; Age: 50; Tissue: lymphocytes (blood);" "Sample Group: control; Gender: male; Age: 60; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 36; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 41; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 43; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 43; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 44; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 50; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 56; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: female; Age: 61; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: male; Age: 51; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: male; Age: 55; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: male; Age: 59; Tissue: lymphocytes (blood);" "Sample Group: HD patient; Gender: male; Age: 62; Tissue: lymphocytes (blood);" !Sample_molecule_ch1 "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" "total RNA" !Sample_extract_protocol_ch1 "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." "TRIzol (Invitrogen) following the manufacturer's protocol, followed by RNeasy column cleanup and ethanol precipitation." !Sample_label_ch1 "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" "Biotin" !Sample_label_protocol_ch1 "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix GeneChip® IVT Labeling Kit, according to manufacturer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" !Sample_hyb_protocol "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix Eukaryotic Target Hybridization protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" !Sample_scan_protocol "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" "Affymetrix® GeneChip® Scanner 3000 with GCOS software according to manufactuer's protocol (GeneChip® Expression Analysis Technical Manual 701021 Rev. 5)" !Sample_description "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" "Affymetrix U133 Human Genome 2.0 Plus arrays" !Sample_data_processing "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." "Probe set summarization and normalization was performed by robust multi-array averaging (RMA, including background subtraction, summarization by median polish and quantile normalization) using the R/Bioconductor package affy." !Sample_platform_id "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" "GPL570" !Sample_contact_name "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" "Alexandre,,Kuhn" !Sample_contact_email "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" "alexandre.kuhn@epfl.ch" !Sample_contact_laboratory "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" "Laboratory of Functional Neurogenomics" !Sample_contact_department "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" "Life Sciences" !Sample_contact_institute "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" "EPFL" !Sample_contact_address "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" "Station 15" !Sample_contact_city "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" "Lausanne" !Sample_contact_zip/postal_code "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" "1015" !Sample_contact_country "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" "Switzerland" !Sample_supplementary_file "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217766/GSM217766.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217767/GSM217767.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217768/GSM217768.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217769/GSM217769.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217770/GSM217770.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217771/GSM217771.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217772/GSM217772.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217773/GSM217773.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217774/GSM217774.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217775/GSM217775.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217776/GSM217776.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217777/GSM217777.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217778/GSM217778.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217779/GSM217779.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217780/GSM217780.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217781/GSM217781.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217782/GSM217782.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217783/GSM217783.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217784/GSM217784.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217785/GSM217785.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217786/GSM217786.CEL.gz" "ftp://ftp.ncbi.nih.gov/pub/geo/DATA/supplementary/samples/GSM217787/GSM217787.CEL.gz" !Sample_data_row_count "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" "54675" !series_matrix_table_begin "ID_REF" "GSM217766" "GSM217767" "GSM217768" "GSM217769" "GSM217770" "GSM217771" "GSM217772" "GSM217773" "GSM217774" "GSM217775" "GSM217776" "GSM217777" "GSM217778" "GSM217779" "GSM217780" "GSM217781" "GSM217782" "GSM217783" "GSM217784" "GSM217785" "GSM217786" "GSM217787" "1007_s_at" 4.47074316754844 4.10637149824957 4.25072270233564 4.30739235730557 4.47275130515484 4.43107152727652 4.43834708501456 4.66119277226342 4.38554130051734 4.57427634350968 4.151352874911 4.85800031536422 4.18316442838686 4.49096074539868 4.47974843711278 4.74399076362218 4.76157086849838 5.05640303381808 4.64608655334802 4.24849907154829 4.48289256456044 4.42902438954133 "1053_at" 4.24053947797407 3.88452439057053 4.40629831454779 4.49561549285029 4.44938838518834 4.47405482873298 4.61225502789463 4.63678665475984 4.75557429779874 3.94693954681206 4.56743613428696 4.4212962616655 4.45988397177997 4.44218334473026 4.18573140815275 4.44672930812943 4.73793421975966 4.12814786012163 4.64652346753641 4.65650026209548 4.42769511720632 4.51792106601821 "117_at" 7.0100328865691 6.1599364229388 7.3894807949017 7.164196408985 5.88153810470004 6.53062324007693 6.28187832738866 6.93420026366502 6.16321512170338 4.74280137357943 6.82092393180381 6.60508303464624 6.27419531747086 6.26470984012228 6.63287011967196 5.89971374636223 6.49536487590828 5.91507689342313 7.20798642898836 7.14216107871584 6.13624510218968 5.5527214602771 "121_at" 5.12429589706945 5.28877298794754 4.89888551162754 5.09057372361871 5.0335920631008 4.89981249179969 5.01273918258307 5.06684719598678 4.93314399302632 5.18128999429753 5.02764272425114 5.08962211312905 4.87680325700665 5.16602663051223 5.49887627448721 5.24122723308137 5.177292133532 5.36294728322084 5.30874036462648 4.96502177126268 5.24211434550003 4.84801868540731 "1255_g_at" 2.50156678620038 2.50675024738932 2.53007710364404 2.5476765209604 2.53804931254542 2.41358363735393 2.44060823685234 2.54803695403957 2.61524614214074 2.41963780543497 2.66695367257298 2.4460890959257 2.56166176304237 2.5487114744533 2.52397001334444 2.64830138913297 2.56753591824902 2.54091809941259 2.46873578213592 2.51531719541879 2.55622851691960 2.52812682650578 "1294_at" 7.67586399910745 7.8126483955632 7.52912903575215 7.33033819385312 7.66124330902971 7.35875921305729 7.57418019403376 7.46218263401262 6.97029173411926 8.02122092814207 7.55445289829414 7.69475407173505 7.47984107792957 7.87908161731096 7.27784196003476 8.1007905163691 7.25317169409882 8.19614369895814 7.82854084198124 7.38241659750138 7.38419390101604 7.44974624080755 "1316_at" 3.62365131948419 3.77092019060199 3.68390942160408 3.50450998248005 3.61911315598327 3.69353126844332 3.44110597826735 3.61215194906430 3.92256371364976 3.57103305118543 3.73085259926971 3.64405132652733 3.43840604234085 3.50335142799533 3.59253262581075 3.98633274661054 3.4912143972367 3.86033829255234 3.59568141362598 3.70142837655534 3.58262082737523 3.62032203096478 "1320_at" 3.07385243545399 3.08832079362117 3.18548341092732 3.00729927948478 2.88248031232214 2.85559790919816 3.06416634453009 3.0753525157333 3.91846867500477 2.81220594960406 3.45599737916266 2.88106813908285 3.02879913479543 3.02349256213442 2.93756148989535 3.12763043353941 3.21625593555265 3.57837881616686 3.18746002114918 3.85310867558192 2.78789437069894 3.05680224889980 "1405_i_at" 9.71912973171442 10.1336200737459 9.82804444453857 10.7356201462634 10.5774131436298 10.7823507909377 10.1309210025338 9.51665610480095 10.2163349215448 9.60128435799525 9.22168712924666 10.1071170917346 9.93207011280832 9.40343850382112 9.27750215945417 10.3027422490305 10.3348889282113 9.4434718499778 10.9816260921748 9.0911799910298 10.5098652704957 11.0645122574401 "1431_at" 2.62654671119773 2.43106711484936 2.61046299811337 2.6183374339401 2.53388217868046 2.49860016659949 2.57285192397505 2.58635004421214 2.90141302413223 2.70218697564296 2.85297447335944 2.60442236774736 2.64052511207305 2.69012778349021 2.61745552003205 2.56129506787969 2.60631462591348 2.66988728621228 2.54795113665063 2.75618233280948 2.56965978147969 2.60845965429357 "1438_at" 3.46451254616812 3.36999549327517 3.39941166633093 3.50912859278836 3.4442301748864 3.27385608181084 3.30120359053481 3.67375480838115 4.24862026786686 3.45734742394179 4.14685952731715 3.53081304467008 3.50129895442269 3.39906109798118 3.51081673137576 3.46306982635253 3.64913294405038 3.48849869292632 3.38008045497416 3.76452251832225 3.32978101561179 3.50252698668888 "1487_at" 5.50999238818234 5.03027154747396 5.27818157179919 5.41901180548948 5.27313879887488 5.17342453367172 5.16923398802527 5.49094757876007 4.73732130189561 4.98775809792468 4.67906975637988 5.10312507404803 5.33582456147602 5.40402397542249 5.00643453129152 5.20263389128334 5.13682849127195 5.07251050942228 5.52174522916888 5.27804195948164 5.14373141265044 5.27024139541469 "1494_f_at" 3.21760350770810 3.35217049372420 3.35479188214265 3.19131806154603 3.26084031071277 3.08187222512905 3.11547067191941 3.40976444858603 3.95356642139271 3.05438219331022 3.71595204761863 3.49108655351315 3.42791009702496 3.19216691480018 3.33955853374713 3.63703772550846 3.42218109603109 3.58445773727437 3.3283448099886 3.53308909553405 3.42910791876609 3.27782796824602 "1552256_a_at" 4.60067198489698 4.31106436093113 4.80208552225837 4.58124059254339 3.94345633359514 4.69599379596636 4.57950078622705 4.77753280923402 4.86943017712558 4.25520382992569 4.57007088563340 4.07358473413524 4.63339104715708 4.5951418174151 4.28575102638168 4.25629799202402 4.45145882466838 4.40507103827152 4.83595871018975 5.30846602306766 4.52872921827077 4.77964843443524 "1552257_a_at" 4.98911147798633 4.76258627111706 4.66369407615764 4.85637439379453 4.71377913970879 4.83477785000361 4.87441024701331 5.05720407038941 4.71540847036995 4.62274831415455 4.61087206616024 4.65112751127178 4.64433905193145 4.80364190098802 4.54607606994582 4.91515128654688 4.73866682761683 4.31674807971735 5.1276129291985 4.71377913970879 4.84678488576602 5.03061341463051 "1552258_at" 3.37469906383008 2.82075395507901 3.26279001465896 3.24130367080851 3.19736585538497 3.25181045933857 3.31232954953057 3.20143175640947 3.23198941041912 2.77030774334974 3.2067965588099 3.52368215761662 3.32744176359075 3.38489134768187 3.22307729697354 3.37549121198231 3.25642749214890 3.04172411043151 3.36442056418289 3.39544237091697 3.10119845586344 3.55145436912625 "1552261_at" 3.30779606221304 3.51065048839667 3.51572413082909 3.13880704045110 3.38951221729277 3.0320356861894 3.19676003773681 3.64222222834453 5.19410274102396 3.35010626093449 4.93569893963886 3.22200134068658 3.19454463276441 3.12181104848252 3.44677987854317 3.37621789875096 3.43656940350000 3.30778608855181 3.46613810104361 4.26836316539449 3.30046878528402 3.47289236003629 "1552263_at" 5.66129907297393 4.57636892560202 5.21968131605919 5.8661642200938 5.22795148270084 5.87398606324333 5.45915845979654 5.75183783344333 4.43419266739398 4.91085414773033 3.49909609791955 5.1523409990292 5.60528967209558 5.24035970263003 4.98753154663323 5.027235926691 5.14939285360053 4.20791320948737 5.20906915273989 4.71022421295019 5.71396628712351 5.5089586259921 "1552264_a_at" 5.05504182637033 4.6722572837233 5.65022165488539 6.54681102362687 5.708538768305 5.84216865177084 5.95416075403662 5.75365000183361 5.23938598061588 5.11935651496864 5.23087113430825 5.66028110772705 5.80507280737128 5.90270431276476 5.0939004187331 5.00514142085948 6.08300392155694 4.22818112756257 5.46341494365405 5.78938281777168 6.035589564032 5.68343008995596 "1552266_at" 2.42025546506881 2.39684489529338 2.84382527066397 2.47690859572189 2.37512584567116 2.39757433818868 2.62872582596694 2.41838951307199 2.80985406990088 2.33475102526096 2.90510546046825 2.29286253080102 2.54176799904021 2.45045013233369 2.64131141624271 2.65778805045609 2.51216597358421 2.42389459087876 2.38184676129550 2.68986745958502 2.29478173263660 2.58086804750597 "1552269_at" 2.75163469625195 2.53117007079867 2.59244463634613 2.55354237997579 2.59432026603702 2.46332555007271 2.51061575947646 2.46305768902915 2.70470015173497 2.61766939230887 2.80790598772206 2.48905290573899 2.41550353436182 2.54025215445957 2.60273014615809 2.64955311767422 2.48227605423855 2.56850710174338 2.55495348377176 2.55921159465464 2.60842216310360 2.52335085447974 "1552271_at" 3.55728138189755 3.75749011332238 3.56282387114624 3.20267313272754 3.61774709227383 3.25530800773701 3.4237848095196 3.75679478243537 4.46488943836783 3.29203781446050 4.04161756052961 3.44841320701382 3.55978402665564 3.49332304697037 3.64830206816865 3.55781860102783 3.56188750054407 3.82193519991902 3.51261823013151 4.22757521199261 3.63210675649236 3.56735780376211 "1552272_a_at" 3.31179448593526 3.56169865331326 3.27458897045492 3.28751030424843 3.13598359717537 3.01912436834981 3.18451442383461 3.27366289166608 4.00683715244132 3.552040862522 3.89967577407163 3.0965957120348 3.21938710698438 3.16509292517857 3.32824999402454 2.91356254081591 3.09004459526364 3.49277156213796 3.2514226192022 3.86077374170464 3.27187918252821 3.31395270255416 "1552274_at" 5.04118216014802 5.22189086427269 5.10865723542137 5.11078416281155 4.80427470097212 5.64271102639681 5.18117233326646 5.4531396820975 3.90251344320635 5.83545859498124 4.27000879036217 5.07446666171635 5.93240980103984 4.84996210704352 5.51355648855218 5.09663842408875 5.49684536938278 4.79717355292320 5.33870029467908 5.18766609999059 4.62091922826892 5.6857638761831 "1552275_s_at" 3.8863278235572 3.74256286817683 3.711584339175 3.78892718677553 4.01094105449951 4.74068420268519 4.59406814901306 4.20787964135994 3.70944805352208 4.1474236372727 3.76379413013795 4.30212246362205 4.54917503105027 3.94968068127996 3.91790601429715 3.7459726338248 4.65558361951979 3.56886033681346 4.18381372614359 3.85010210776227 4.25997171188846 3.95728917490049 "1552276_a_at" 4.38050153324672 3.91453334647106 4.39701499213914 4.08529537516546 3.87960059799074 3.69376408767875 3.88245660728578 4.14503526866630 4.17380931132016 3.98795936878360 4.37195360640776 4.07916798553793 3.97022621884546 4.04466689207010 4.14633142035254 3.91964616045074 3.93088447474835 3.99693519291082 3.89290274416322 3.88834287396743 3.87960059799074 3.87336288043974 "1552277_a_at" 3.96975246055337 4.24052268925945 3.98139930650943 4.33403040560378 4.34854574744397 4.26752361055993 4.12017874648907 3.7665827420392 3.69834269772608 4.09613313920873 3.9001555199013 4.48814442591606 3.87538709818674 4.14395031629631 3.69834269772608 4.48827585157072 4.58019964757333 4.24828325206369 5.34531097294947 3.70922593797009 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